Abstract
AbstractBackground:Krukenberg tumors are ovarian metastatic adenocarcinomas with a primary origin usually located in the stomach, colon, gallbladder, pancreas, or breast. Occasionally, these tumors produce virilization in the affected individual due to androgen production by luteinization of the tumoral stroma. It is believed that during pregnancy these tumors are more likely to increase androgen production due to the elevated levels of human chorionic gonadotropin (hCG). High maternal androgens can cross the placenta producing virilization of the female fetus.Case presentation:A 46,XX newborn female, whose mother was diagnosed with a metastatic ovarian tumor during her second trimester of gestation associated with worsening hirsutism and acne, was found to have ambiguous genitalia at birth. Testosterone levels in both the mother and infant were elevated. Follow-up laboratory tests showed progressive normalization of circulating androgens after delivery.Conclusions:Krukenberg tumors are rare and may produce virilization of the mother and the female fetus when present during pregnancy.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology, and Child Health
Reference46 articles.
1. Developmental and functional biology of the primate fetal adrenal cortex;Endocr Rev,1997
2. Recurrent severe hyperandrogenism during pregnancy: a case report;J Clin Pathol.,2005
3. Clinical and ultrastructural findings of an androgenizing Krukenberg tumor in pregnancy;Obstet Gynecol,1988
4. Luteoma of pregnancy associated with nearly complete virilization of genetically female twins;Endocr Pract,2014
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Molecular pathways in placental-fetal development and disruption;Molecular and Cellular Endocrinology;2024-02
2. Hypergonadism;Steroids in the Laboratory and Clinical Practice;2023
3. Clinical spectrum of female genital malformations in prenatal diagnosis;Archives of Gynecology and Obstetrics;2022-02-27
4. Disorders of Sex Development;Pediatrics In Review;2021-08-01
5. Disorders of sexual development;Handbook of Diagnostic Endocrinology;2021