A New Tetrahydrofuran Derivative from the Endophytic Fungus Chaetomium sp. Isolated from Otanthus maritimus-Reference-Cited by-同舟云学术

A New Tetrahydrofuran Derivative from the Endophytic Fungus Chaetomium sp. Isolated from Otanthus maritimus

Published:2009-06-01 Issue:5-6 Volume:64 Page:350-354
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Aly Amal H.¹²,Debbab Abdessamad¹,Edrada-Ebel RuAngelie³,Wray Victor⁴,Müller Werner E. G.⁵,Lin Wenhan⁶,Ebel Rainer⁷,Proksch Peter¹

Affiliation:

1. Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Universitätsstraße 1, Geb. 26.23, D-40225 Düsseldorf, Germany

2. Permanent address: Department of Pharmacognosy, Faculty of Pharmacy, Khartoum Sq. Azarita, Alexandria, Egypt

3. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK

4. Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany

5. Institut für Physiologische Chemie und Pathobiochemie, Johannes-Gutenberg-Universität, Duesbergweg 6, D-55128 Mainz, Germany

6. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, People’s Republic of China

7. Department of Chemistry, University of Aberdeen, Meston Building, Meston Walk, Old Aberdeen AB24 3UE, Scotland, UK.

Abstract

1 A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (), along with 5 known natural products, 2 - 6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50 values of 7.0 and 2.7 μg/mL, respectively, whereas 1 was inactive

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2009-5-608/pdf

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