Affiliation:
1. Faculty of Mechanical Engineering and Automation, Liaoning University of technology, Jinzhou 121001, China
Abstract
Abstract
Microfluidic mixing is an essential part of the process of microfluidic chip technology in the analysis, and micromixer has also become the key components of microfluidic chip analysis system. For DNA hybridization, protein folding and enzyme reaction, some biochemical processes need to react quickly to achieve on analysis and research has the vital significance. A simple, rapid and low-cost passive micromixer is presented in this paper. In order to improve the mixing efficiency of the species, the concept of a splitting and recombination (SAR) was used to shorten the mixing time of the species. This study simulated the species mixing in a micromixer with traditional T-type micromixer and diamond-like micropillar in laminar flow state through COMSOL multiphysics 3.5a to computational fluid dynamics (CFD). Linking artificial neural network (ANN) and CFD was used to optimize the diamond-like micropillar. Finally, simulation results proved that the micromixer with SAR diamond-like concept achieves a high-efficiency mixing than T-type micromixer. Numerical results also show that the mixing efficiency of the SAR micromixer with diamond-like micropillar can be up to 99 %, and that efficiency can reach rapidly 90 % in a short channel distance.
Subject
General Chemical Engineering
Reference22 articles.
1. 1. Abdelhay, A., 2002. Application of artificial neural networks to predict the carbon content and the grain size for carbon steels. Egyptian Journal of Solids 25, 229–243.
2. 2. Bessoth, F. G., deMello, A. J., Manz, A., 1999. Microstructure for efficient continuous flow mixing. Analytical Communications 36(6), 213–215.
3. 3. Bhagat, A. A. S., Peterson, E. T. K., Papautsky, I., 2007. A passive planar micromixer with obstructions for mixing at low Reynolds numbers. Journal of Micromechanics and Microengineering 17, 1017–1024.
4. 4. Branebjerg, J., Fabius, B., Gravesen, P., 1994. Application of miniature analyzers: from microfluidic components to μTAS. Proceedings of Micro Total Analysis Systems Conference, Twente, Netherlands, pp. 141–151.
5. 5. Branebjerg, J., Gravesen, P., Krog, J. P., Nielsen, C. R., 1996. Fast mixing by lamination. Proceedings of the IEEE Micro Electro Mechanical Systems. San Diego, USA, pp. 441–446.
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