1. Department of Integrative Medicine , Federal University of Parana , Curitiba , Brazil
2. Laboratory of Statistics and Geoinformation, Department of Statistics , Federal University of Parana , Curitiba , Brazil
3. Research Group of Technology Applied to Optimization (GTAO) , Federal University of Parana , Curitiba , Brazil
4. Internal Medicine , Federal University of Parana , Curitiba , Brazil
5. Endocrine Division, Hospital de Clínicas da Universidade Federal do Paraná (SEMPR) , Federal University of Parana , Curitiba , Brazil