Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol-Reference-Cited by-同舟云学术

Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol

Published:2011-06-01 Issue:5-6 Volume:66 Page:199-204
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Li Ning¹²,Huang Yuan¹,Xiao Wan¹,Li Xian¹,Li Pingya²,Liu Jinping²

Affiliation:

1. School of Traditional Chinese Materia Medica 49#, Key Laboratory of Structure- Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China

2. Institute of Frontier Medical Science, Jilin University, Changchun 130021, China

Abstract

In order to find new lead compounds with antitumour activies, thirteen new fatty acid esters of 20(S)-protopanaxadiol (PPD) were synthesized using oleoyl chloride or fatty acids and N,N’-dicyclohexylcarbodiimide (DCC). Their cytotoxic activities were tested using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] method, and the structure- activity relationships between the fatty acid esters of PPD and their cytotoxic activities are discussed.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2011-5-601/pdf

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