Site-Specific in vivo Targeting of Magnetoliposomes Using Externally Applied Magnetic Field-Reference-Cited by-同舟云学术

Site-Specific in vivo Targeting of Magnetoliposomes Using Externally Applied Magnetic Field

Published:2000-04-01 Issue:3-4 Volume:55 Page:278-281
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Babincová Melánia¹,Altanerová Veronika²,Lampert Miloš³,Altaner Čestmír²,Machová Eva⁴,rámka Miron Š²,Babinec Peter⁵

Affiliation:

1. Department of Biophysics, Comenius University. Mlynská dolina F1, 84215 Bratislava, Slovakia. Fax: +(421)-7 -654 -25 -882

2. Cancer Research Institute, Slovak Academy of Sciences, 83391 Bratislava, Slovakia

3. Department of Neurosurgery, Derer's Faculty Hospital, Limbová 5, Bratislava, Slovakia

4. Institute of Chemistry, Slovak Academy of Sciences, Dúbravská 9, Bratislava, Slovakia

5. Department of Biophysics, Comenius University. Mlynská dolina F1, 84215 Bratislava, Slovakia.

Abstract

Abstract Human serum albumin labeled with technetium-99m was encapsulated together with magnetite particles into phosphatidylcholine/cholesterol liposomes. In order to investigate the stability of this complex and its ability to be used for magnetic drug targeting, the in-vivo distribution after intravenous administration in rats was estimated. For in-vivo targeting an SmCo permanent magnet with intensity ~ 0.3 5 T was attached near the right kidney. Difference between the relative radioactivity in the magnetically targeted right kidney (25.92±5.84%) and non-targeted left kidney (0.93±0.05%) is sufficiently high for relevant clinical applications.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2000-3-422/pdf

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