Evaluation of 186WS2 target material for production of high specific activity 186Re via proton irradiation: separation, radiolabeling and recovery/recycling-Reference-Cited by-同舟云学术

Evaluation of ¹⁸⁶WS₂ target material for production of high specific activity ¹⁸⁶Re via proton irradiation: separation, radiolabeling and recovery/recycling

Published:2022-04-21 Issue:6-9 Volume:110 Page:739-749
ISSN:0033-8230
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Charles Anster¹,Khosrashahi Firouzeh Najafi¹,Ma Li¹,Munindradasa Chathurya¹,Hoerres Rebecca¹,Lydon John D.²,Kelley Steven P.¹,Guthrie James²,Rotsch David³,Medvedev Dmitri⁴,Cutler Cathy S.⁴,Li Yawen⁵,Wilbur D. Scott⁵,Hennkens Heather M.¹²,Jurisson Silvia S.¹

Affiliation:

1. Department of Chemistry , University of Missouri , Columbia , MO , USA

2. University of Missouri Research Reactor Center (MURR) , Columbia , MO , USA

3. Argonne National Laboratory , Lemont , IL , USA

4. Collider Accelerator Department , Brookhaven National Laboratory , Upton , NY , USA

5. Department of Radiation Oncology , University of Washington , Seattle , WA , USA

Abstract

Abstract Enriched tungsten disulfide (186WS2) was evaluated at increasing proton beam currents (20–50 μA) and times (up to 4 h) on a GE PETtrace cyclotron for production of high specific activity (HSA) 186Re. The HSA 186Re was separated from the irradiated target as [186Re][ReO4]– by a liquid–liquid extraction method and radiolabeled with a new N2S2 ligand (222-MAMA-N-ethylpropionate). The enriched 186W was recovered from the extraction process, analyzed for purity and enrichment, and converted back to the disulfide (186WS2). The results demonstrate that the 186WS2 is an easily pressed target material that can withstand relatively high currents and can be readily recovered and recycled. The 186Re produced was isolated in high specific activity and readily formed the radiotracers [186Re][ReO(222-MAMA-N-ethylpropionate)] and [186Re][Re(CO)3(OH2)3] +.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2021-1138/pdf

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