Hepatic stellate cells: current state and open questions
Author:
Kordes Claus1ORCID, Bock Hans H.1, Reichert Doreen1, May Petra1, Häussinger Dieter1
Affiliation:
1. Clinic of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University , Moorenstraße 5 , D-40225 Düsseldorf , Germany
Abstract
Abstract
This review article summarizes 20 years of our research on hepatic stellate cells within the framework of two collaborative research centers CRC575 and CRC974 at the Heinrich Heine University. Over this period, stellate cells were identified for the first time as mesenchymal stem cells of the liver, and important functions of these cells in the context of liver regeneration were discovered. Furthermore, it was determined that the space of Disse – bounded by the sinusoidal endothelium and hepatocytes – functions as a stem cell niche for stellate cells. Essential elements of this niche that control the maintenance of hepatic stellate cells have been identified alongside their impairment with age. This article aims to highlight previous studies on stellate cells and critically examine and identify open questions and future research directions.
Publisher
Walter de Gruyter GmbH
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
Reference111 articles.
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