Affiliation:
1. Goldberg Research Institute of Pharmacology and Regenerative Medicine (GRIPRM), Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
2. Research Institute of General Pathology and Pathophysiology
Abstract
The processes of proliferation and differentiation of progenitor and stem cells in the body are ensured by a specific microenvironment, the stem cell niche. Universal components have been identified for all niches: supporting cells, extracellular matrix, and soluble biological factors. A niche is a dynamic system whose activity depends on regeneration needs.The review presents data on the structure of the hepatic stem cell niche and one of its main components – stellate cells and their role in pathology.
Publisher
Siberian State Medical University
Reference64 articles.
1. Gol'dberg E.D., Dygai A.M., Zhdanov V.V. Rol' gemopoezindutsiruyushchego mikrookruzheniya v regulyatsii krovetvoreniya pri tsitostaticheskikh mielosupressiyakh. Tomsk: STT, 1999:128.
2. Dygai A.M., Zhdanov V.V. Teoriya regulyatsii krovetvoreniya. M.: Izd-vo RAMN, 2012:140.
3. Fuchs E., Blau H.M. tissue stem cells: architects of their niches. Cell Stem Cell. 2020;27(4):532–556. DOI: 10.1016/j.stem.2020.09.011.
4. Martinez P., Ballarin L., Ereskovsky A.V. et al. Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates. BMC Biol. 2022;(1):20:23. DOI: 10.1186/s12915-022-01230-5.
5. Yushkov B.G., Klimin V.G. Povrezhdenie i regeneratsiya. M., 2017:132.