Carotenoids in Sporidiobolus pararoseus ameliorate diabetic nephropathy in mice through attenuating oxidative stress-Reference-Cited by-同舟云学术

Carotenoids in Sporidiobolus pararoseus ameliorate diabetic nephropathy in mice through attenuating oxidative stress

Published:2021-03-15 Issue:0 Volume:0 Page:
ISSN:1437-4315
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Du Chao¹²³,Lv Tianqi³,Liu Quanwen¹²,Cheng Yuliang³,Liu Chang³,Han Mei⁴,Zhang Weiguo⁴,Qian He³⁵

Affiliation:

1. School of Food Engineering, Ludong University , 186 Middle Hongqi Road , Yantai 264025 , Shandong Province , P. R. China

2. BioNanotechnology Institute, Ludong University , 186 Middle Hongqi Road , Yantai 264025 , Shandong Province , P. R. China

3. School of Food Science and Technology, Jiangnan University , Wuxi , P. R. China

4. School of Biotechnology, Jiangnan University , Wuxi , P. R. China

5. Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University , 1800 Lihu Avenue , Wuxi 214122 , Jiangsu Province , P. R. China

Abstract

Abstract Diabetic nephropathy (DN) is the major life-threatening complication of diabetes, and oxidative stress takes part in its initiation and development. This study was performed to evaluate the effects of carotenoids from Sporidiobolus pararoseus (CSP) on the renal function and oxidative stress status of mice with streptozotocin (STZ)-induced DN. The results indicated that CSP significantly attenuated symptoms of STZ-induced DN shown by decreased fasting blood glucose, reduced urine volume, urine albumin, serum creatinine and serum urea nitrogen, and improved kidney histological morphology. Furthermore, biochemical analysis of serum and kidney revealed a marked increase in oxidative stress of DN mice as evidenced by reduced total antioxidant capacity (T-AOC), decreased activity of antioxidant enzyme -superoxide dismutase (SOD) and increased level of malondialdehyde (MDA). However, treatment with CSP improved oxidative stress status in DN mice as compared with the mice in model group. Exploration of the potential mechanism validated that CSP ameliorated the oxidative stress status in DN mice by activating the expressions of Nrf2, NQO-1, HO-1, GST and CAT in kidney. These data revealed that CSP may retard the progression of DN by ameliorating renal function, improving the oxidative stress status and activating the Nrf2/ARE pathway.

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Reference40 articles.

1. Afshari, A.T., Shirpoor, A., Farshid, A., Saadatian, R., Rasmi, Y., Saboory, E., Ilkhanizadeh, B., and Allameh, A. (2007). The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rats. Food Chem. 101: 148–153, https://doi.org/10.1016/j.foodchem.2006.01.013.

2. Ahmed, S., Mundhe, N., Borgohain, M., Chowdhury, L., Kwatra, M., Bolshette, N., Ahmed, A., and Lahkar, M. (2016). Diosmin modulates the NF-κB signal transduction pathways and downregulation of various oxidative stress markers in alloxan-induced diabetic nephropathy. Inflammation 39: 1783–1797, https://doi.org/10.1007/s10753-016-0413-4.

3. Badal, S.S. and Danesh, F.R. (2014). New insights into molecular mechanisms of diabetic kidney disease. Am. J. Kidney Dis. 63: S63–83, https://doi.org/10.1053/j.ajkd.2013.10.047.

4. Bayrasheva, V.K., Babenko, A.Y., Dobronravov, V.A., Dmitriev, Y.V., Chefu, S.G., Pchelin, I.Y., Ivanova, A.N., Bairamov, A.A., Alexeyeva, N.P., Shatalov, I.S., et al.. (2016). Uninephrectomized high-fat-fed nicotinamide-streptozotocin-induced diabetic rats: a model for the investigation of diabetic nephropathy in type 2 diabetes. J. Diabetes Res. 2016: 8317850, https://doi.org/10.1155/2016/8317850.

5. Cheng, Y., Liu, C., Cui, Y., Lv, T., Guo, Y., Liang, J., and Qian, H. (2019). Sporidiobolus pararoseus wall-broken powder ameliorates oxidative stress in diabetic nephropathy in type-2 diabetic mice by activating the Nrf2/ARE pathway. RSC Adv. 9: 8394–8403, https://doi.org/10.1039/c8ra10484k.

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Effect of trace elements and nutrients on diabetes and its complications: a Mendelian randomization study;Frontiers in Nutrition;2024-08-01

2. A MUFA/carotenoid-rich oil ameliorated insulin resistance by improving inflammation and oxidative stress in obese rats;Molecular and Cellular Endocrinology;2024-02

3. Phytochemical study and Protective Effect of Trigonella foenum-graecum (Fenugreek Seeds) Methanolic Extract Underlying the Mechanism of Action on Diabetic Nephropathy in Experimental Rats;Current Drug Therapy;2023-08-16

4. Retinol intake is associated with the risk of chronic kidney disease in individuals with type 2 diabetes mellitus: results from NHANES;Scientific Reports;2023-07-18

5. Inverse correlations between serum carotenoids and respiratory morbidity and mortality: the Third National Health and Nutrition Examination Survey;British Journal of Nutrition;2023-04-11