Synthesis, characterization and in vitro activity study of some organotin(IV) carboxylates against leukemia cancer cell, L-1210-Reference-Cited by-同舟云学术

Synthesis, characterization and in vitro activity study of some organotin(IV) carboxylates against leukemia cancer cell, L-1210

Published:2023-04-17 Issue:0 Volume:0 Page:
ISSN:2365-6581
Container-title:Physical Sciences Reviews
language:en
Short-container-title:

Author:

Hadi Sutopo¹^ORCID,Winarno Ermin Katrin¹,Winarno Hendig¹,Berawi Khairun Nisa²,Suhartati Tati³,Yandri Yandri³,Simanjuntak Wasinton³

Affiliation:

1. Research Center for Radiation Process Technology, Research Organization for Nuclear Energy (BATAN) – National Research and Innovation Agency (NRIA) , Gedung 90, KST B.J. Habibie, Jl. Puspiptek, Muncul, Kec. Setu , Tangerang Selatan , Banten 15314 , Indonesia

2. Medical Faculty, Universitas Lampung , Bandar Lampung , 35145 , Indonesia

3. Department of Chemistry , University of Lampung , Bandar Lampung 35145 , Indonesia

Abstract

Abstract This paper presents successful resynthesizing of several dibutyl-, diphenyl-, and triphenyltin(IV) carboxylate compounds, and their activity against leukemia cancer cell, L-1210. The compounds were synthesized by reacting the dibutyltin(IV) oxide (DBTO) (1), diphenyltin(IV) oxide (DPTO) (3), and triphenyltin(IV) hydroxide (TPTOH) (5) with 3-hydroxybenzoic acid (3-HHBz). Prior to cancer activity tests, the compounds were characterized by UV–Vis, FT-IR, NMR (both 1H NMR and 13C NMR), and microanalysis to determine elemental composition of the samples. The anticancer tests revealed that triphenyltin(IV) 3-hydroxybenzoate (TPTHBz) (6) displayed significantly higher activity than those exhibited by dibutyltin(IV) di(3-hydroxybenzoate) (DBTHBz) (2) and diphenyltin(IV) di(3-hydroxybenzoate) (DPTHBz) (4).

Publisher

Walter de Gruyter GmbH

Subject

General Physics and Astronomy,General Materials Science,General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/psr-2022-0303/pdf

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