Synthesis and in vitro activity investigation of some dibutyl-, diphenyl- and triphenyltin(IV) carboxylates against leukemia cancer cell, L-1210
Author:
Hadi Sutopo1, Winarno Ermin Katrin2, Winarno Hendig2, Berawi Khairun Nisa3, Suhartati Tati1, Noviany Noviany1, Simanjuntak Wasinton1, Yandri Yandri1
Affiliation:
1. Department of Chemistry , University of Lampung , Bandar Lampung 35145 Indonesia 2. Research Center for Radiation Process Technology , National Research and Innovation Agency , KST B.J. Habibie , Tangerang Selatan , Banten 15314 , Indonesia 3. Medical Faculty , Universitas Lampung , Bandar Lampung 35145 , Indonesia
Abstract
Abstract
Successful synthesis of several dibutyl-, diphenyl- and triphenyltin(IV) carboxylate compounds and evaluation of their activity as anticancer against leukemia cancer cell, L-1210 was reported. The compounds were synthesized by reacting dibutyltin(IV) oxide (DBTO) (1), diphenyltin(IV) oxide (DPTO) (4) and triphenyltin(IV) hydroxide (TPTOH) (7) with respective carboxylic acids, and subsequently characterized using NMR, FTIR, and UV–Vis spectroscopies, microelemental analyzer, and melting point apparatus. The compounds were then tested as anticancer, revealing that derivatives of triphenyltin(IV) (compounds 8 dan 9) exhibit the IC50 value of 3.7 and 2.9 μg/mL, respectively, which are much higher activity than those of dibutyltin(IV) and diphenyltin(IV) derivatives.
Funder
Universitas Lampung, HETI Project
Publisher
Walter de Gruyter GmbH
Subject
General Chemical Engineering,General Chemistry
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