Determination of the hepatitis C virus subtype: comparison of sequencing and reverse hybridization assays

Abstract

AbstractHepatitis C virus (HCV) genotyping and accurate subtyping is becoming increasingly relevant to epidemiological studies, clinical management, pathogenicity, and vaccine development.The TRUGENEAll amplified samples from among the members of a HCV genotyping proficiency program panel that contained a single HCV genotype were subtyped correctly using all three HCV genotyping assays. With the TRUGENEThe two new methods show advantages over the routinely used TRUGENEClin Chem Lab Med 2007;45:167–70.