Second near-infrared (NIR-II) imaging: a novel diagnostic technique for brain diseases
Author:
Xie Na1, Hou Ya1, Wang Shaohui2, Ai Xiaopeng1, Bai Jinrong1, Lai Xianrong2, Zhang Yi2, Meng Xianli3, Wang Xiaobo3
Affiliation:
1. College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , China 2. Ethnic Medicine Academic Heritage Innovation Research Center, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , China 3. State Key Laboratory of Southwestern Chinese Medicine Resources , Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 , China
Abstract
Abstract
Imaging in the second near-infrared II (NIR-II) window, a kind of biomedical imaging technology with characteristics of high sensitivity, high resolution, and real-time imaging, is commonly used in the diagnosis of brain diseases. Compared with the conventional visible light (400–750 nm) and NIR-I (750–900 nm) imaging, the NIR-II has a longer wavelength of 1000–1700 nm. Notably, the superiorities of NIR-II can minimize the light scattering and autofluorescence of biological tissue with the depth of brain tissue penetration up to 7.4 mm. Herein, we summarized the main principles of NIR-II in animal models of traumatic brain injury, cerebrovascular visualization, brain tumor, inflammation, and stroke. Simultaneously, we encapsulated the in vivo process of NIR-II probes and their in vivo and in vitro toxic effects. We further dissected its limitations and following optimization measures.
Publisher
Walter de Gruyter GmbH
Subject
General Neuroscience
Reference147 articles.
1. Ali, I.U. and Chen, X. (2015). Penetrating the blood-brain barrier: promise of novel nanoplatforms and delivery vehicles. ACS Nano 9: 9470–9474, https://doi.org/10.1021/acsnano.5b05341. 2. Almeida, J.P., Chen, A.L., Foster, A., and Drezek, R. (2011). In vivo biodistribution of nanoparticles. Nanomedicine 6: 815–835, https://doi.org/10.2217/nnm.11.79. 3. Antaris, A.L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al.. (2016). A small-molecule dye for NIR-II imaging. Nat. Mater. 15: 235–242, https://doi.org/10.1038/nmat4476. 4. Antaris, A.L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A.X., Fan, Q., Chew, L., et al.. (2017). A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Nat. Commun. 8: 15269, https://doi.org/10.1038/ncomms15269. 5. Attia, A., Balasundaram, G., Moothanchery, M., Dinish, U.S., Bi, R., Ntziachristos, V., and Olivo, M. (2019). A review of clinical photoacoustic imaging, current and future trends. Photoacoustics 16: 100144, https://doi.org/10.1016/j.pacs.2019.100144.
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|