Infrarot-spektroskopische Untersuchung der Assoziation von Nucleosid-Derivaten in Lösung: Nachweis der Bildung durch Wasserstoffbrücken gebundener Basenpaare

Abstract

Derivatives of adenosine and uridine, which were substituted only at the sugar moiety and which were soluble in CCl4, have been prepared. The concentration-dependencies of the IR-spectra of 2′.3′-Isopropylidene-5′-trityl-adenosine (ITA) and 2′,3′-Isopropylidene-5′-trityl-uridine (ITU) in CCl4 indicated that hydrogen-bonded, cyclic dimers were formed at low concentrations. In solutions of equimolar amounts of ITA and ITU the hetero-associate containing an adenine-uracil-pair was found to be more stable than the homo-associates.