A New Sesquiterpene Lactone Sulfate from Reichardia gaditana (Asteraceae)

Author:

Zidorn Christian1,Ellmerer Ernst-Peter2,Heller Werner3,Greil Richard45,Guggenberger Manuela1,Ongania Karl-Hans2,Stuppner Hermann1

Affiliation:

1. Institut für Pharmazie, Abteilung Pharmakognosie, Universität Innsbruck, Innrain 52, A-6020 Innsbruck, Austria

2. Institut für Organische Chemie, Universität Innsbruck, Innrain 52, A-6020 Innsbruck, Austria

3. GSF Forschungszentrum für Umwelt und Gesundheit, Institut für Biochemische Pflanzenpathologie, AG Sekundärstoffwechsel, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany

4. Tiroler Krebsforschungsinstitut, Innrain 66, A-6020 Innsbruck, Austria

5. Third Medical Department at the Paracelsus Private University Hospital Salzburg, 5020 Salzburg, Austria

Abstract

The new sesquiterpenoid 8-deoxy-15-(3′-hydroxy-2′-methyl-propanoyl)-lactucin 3′-sulfate (1) was isolated from the methanolic extract of roots of Reichardia gaditana L. The compound was isolated by silica gel column chromatography (CC) and repeated Sephadex LH-20 CC. Structure elucidation was accomplished by high-resolution mass spectrometry and by 1D- and 2D-NMR spectroscopy. The chemosystematic significance of the new compound is discussed in the context of sesquiterpenoids from other members of the Lactuceae tribe of the Asteraceae family.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

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