Synthesis and anti-proliferative activity of pyridine O-galactosides and 4-fluorobenzoyl analogues-Reference-Cited by-同舟云学术

Synthesis and anti-proliferative activity of pyridine O-galactosides and 4-fluorobenzoyl analogues

Published:2015-10-01 Issue:5 Volume:21 Page:285-290
ISSN:2191-0197
Container-title:Heterocyclic Communications
language:
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Author:

Alneyadi Shaikha S.¹,Shehadi Ihsan A.²,Abdou Ibrahim M.¹

Affiliation:

1. 1Faculty of Science, Department of Chemistry, United Arab Emirates University, P. O. Box 15551, Al-Ain, UAE

2. 2Faculty of Science, Department of Chemistry, Sharjah University, P. O. Box 27272, Sharjah, UAE

Abstract

AbstractPyridine O-galactosides 3, 4, and 2-(4′-fluorobenzoyloxy)pyridine derivatives 5 were prepared by simple nucleophilic substitution reactions. These nucleosides were studied as anti-proliferating agents of human promyelotic leukemia (HL-60) cells. Compound 5a shows the highest anti-proliferative activity (77% at 100 μm) among the synthesized compounds.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2015-0125/pdf

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