Synthesis and antimicrobial activity of 4-trifluoromethylpyridine nucleosides-Reference-Cited by-同舟云学术

Synthesis and antimicrobial activity of 4-trifluoromethylpyridine nucleosides

Published:2017-06-27 Issue:3 Volume:23 Page:197-203
ISSN:2191-0197
Container-title:Heterocyclic Communications
language:
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Author:

Alneyadi Shaikha S.¹,Abdulqader Anas A.¹,Salem Alaa A.¹,Abdou Ibrahim M.²

Affiliation:

1. Department of Chemistry, College of Science, UAEUAl-Ain 15551, UAE

2. Department of Chemistry, College of Science, UAEUAl-Ain 15551, UAE, Imabdou@gmail.com

Abstract

Abstract4-Trifluoromethylpyridine derivatives 4–8 represent good candidates for the discovery of new antibacterial agents. Fluorinated pyridine nucleosides 4–7 and non-nucleoside analogues 8a,b were synthesized and evaluated for their antibacterial activities against Staphylococcus aureus, Bacillus infantis, Escherichia coli and Stenotrophomonas maltophilia. The minimum inhibitory concentrations (MICs) of the new nucleosides 4–7 range from 1.3 to 4.9 μg/mL and MICs of fluoroaryl derivatives 8a,b are in the range of 1.8–5.5 μg/mL. Activity of amoxicillin, the reference drug, is 1.0–2.0 μg/mL under similar conditions.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2017-0019/pdf

Reference40 articles.

1. Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo;Antimicrob Agents Chemother.,2010

2. Purine nucleoside phosphorylases: properties, functions, and clinical aspects;Pharmacol. Ther.,2000

3. Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo;Antimicrob Agents Chemother.,2010

4. The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors;Med. Res. Rev.,2000

5. Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis;Nat. Prod. Rep.,2003

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