Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats-Reference-Cited by-同舟云学术

Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats

Published:2018-08-03 Issue:1 Volume:16 Page:674-680
ISSN:2391-5420
Container-title:Open Chemistry
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Author:

Shi Yu¹,Wang Feng²,Hu A-Zhen¹,Wang Qing-Wen¹,Wu Jue-Lian¹,Li Ming-Hua¹,Cui Guang-Hui¹,Liu Li¹,Huang Si-Bin³,Zhang Yu⁴,Liu Han-Qing¹,Chen Yun¹

Affiliation:

1. Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036

2. Department of Physiology and Neurobiology, Xinxiang Medical University, No. 601 of Jinsui avenue, Hongqi district, Xinxiang, Henan, China, 453000

3. Xia men 929 bioproducts Co., Ltd, Xia men, Fujian, China, 361100

4. Department of Ultrasound, The Third People’s Hospital of Shenzhen, Shenzhen, Guangdong, China, 5180515

Abstract

AbstractThe aim of this study was to determine the effects of Jinniu Capsule on methamphetamine (METH)-induced conditioned place preference (CPP) in rats and identify the underlying mechanisms. An intraperitoneal injection of 3 mg/kg METH was used for CPP training in rats. The effects of Jinniu Capsule following a single dose on rat CPP and repeat dosing on METH withdrawal were evaluated. Western Blot analysis was used to measure protein expression of the PI3K-AKT-mTOR signaling pathway to determine the mechanisms of Jinniu Capsule. A single dose of Jinniu Capsule did not influence METH-induced CPP in rats. However, repeat dosing for 7 days significantly promoted METH withdrawal. Furthermore, METH withdrawal activated the PI3K-AKT-mTOR signaling pathway phosphorylation cascade, and Jinniu Capsule partly blocked this cascade. Jinniu Capsule demonstrated potential in promoting METH withdrawal in a rat CPP model, which may be related to its influence on the PI3K-AKT-mTOR signaling pathway.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

https://www.degruyter.com/downloadpdf/journals/chem/16/1/article-p674.xml

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