Proteomics research of SARS-CoV-2 and COVID-19 disease-Reference-Cited by-同舟云学术

Proteomics research of SARS-CoV-2 and COVID-19 disease

Published:2022-08-01 Issue:4 Volume:2 Page:427-445
ISSN:2749-9642
Container-title:Medical Review
language:en
Short-container-title:

Author:

Zhang Nan¹²³,Wang Siyuan¹,Wong Catherine C.L.¹⁴^ORCID

Affiliation:

1. Department of Medical Research Center , State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , P. R. China

2. Department of Radiation Oncology , College of Medicine, The Ohio State University , Columbus , OH , USA

3. Center for Cancer Metabolism, Comprehensive Cancer Center, The Ohio State University , Columbus , OH , USA

4. Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University , Beijing , P. R. China

Abstract

Abstract Currently, coronavirus disease 2019 (COVID-19) is still spreading in a global scale, exerting a massive health and socioeconomic crisis. Deep insights into the molecular functions of the viral proteins and the pathogenesis of this infectious disease are urgently needed. In this review, we comprehensively describe the proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and summarize their protein interaction map with host cells. In the protein interaction network between the virus and the host, a total of 787 host prey proteins that appeared in at least two studies or were verified by co-immunoprecipitation experiments. Together with 29 viral proteins, a network of 1762 proximal interactions were observed. We also review the proteomics results of COVID-19 patients and proved that SARS-CoV-2 hijacked the host’s translation system, post-translation modification system, and energy supply system via viral proteins, resulting in various immune disorders, multiple cardiomyopathies, and cholesterol metabolism diseases.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/mr-2022-0016/pdf

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