Synthesis of carbohydrate-substituted isoxazoles and evaluation of their antitubercular activity-Reference-Cited by-同舟云学术

Synthesis of carbohydrate-substituted isoxazoles and evaluation of their antitubercular activity

Published:2017-06-27 Issue:3 Volume:23 Page:225-229
ISSN:2191-0197
Container-title:Heterocyclic Communications
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Author:

Hajlaoui Khaoula¹,Guesmi Ahlem²,Hamadi Naoufel Ben³⁴,Msaddek Moncef¹

Affiliation:

1. Laboratory of Synthesis Heterocyclic and Natural Substances, Department of Chemistry, Faculty of Sciences of Monastir, Monastir, Tunisia

2. Department of Chemistry, College of Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia

3. Laboratory of Synthesis Heterocyclic and Natural Substances, Department of Chemistry, Faculty of Sciences of Monastir, Boulevard of Environment, 5000 Monastir, Tunisia

4. Department of Chemistry, College of Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia

Abstract

AbstractEight new sugar-substituted isoxazoles were synthesized by a 1,3-dipolar cycloaddition reaction of aromatic nitrile oxides with carbohydrate-substituted alkynes. Products were screened for antimycobacterial activity against the Mycobacterium tuberculosis H37Rv strain. Four compounds, 5e–h, significantly inhibit growth of the bacterial strain with a minimum inhibitory concentration (MIC) of 3.125 μg/mL.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2016-0185/pdf

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