Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites-Reference-Cited by-同舟云学术

Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites

Published:2016-11-10 Issue:5-6 Volume:72 Page:173-179
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Aracagök Y. Doruk¹,Göker Hakan²,Cihangir Nilüfer³

Affiliation:

1. Department of Biology, Faculty of Science, Hacettepe University , 06800 Beytepe, Ankara , Turkey , Phone: +903122978024

2. Central Instrumental Analysis II Laboratory, Faculty of Pharmacy, Ankara University , 06100 Tandoğan, Ankara , Turkey

3. Department of Biology, Faculty of Science, Hacettepe University, 06800 Beytepe , Ankara , Turkey

Abstract

Abstract Pharmaceuticals are widely used for treating human and animal diseases. Naproxen [(S) 6-methoxy-α-methyl-2-naphthalene acetic acid] and its sodium salt are members of the α-arylpropionic acid group of nonsteroidal anti-inflammatory drugs. Due to excessive usage of naproxen, this drug has been determined even in drinking water. In this study, four fungal strains Phanerochaete chrysosporium, Funalia trogii, Aspergillus niger, and Yarrowia lipolytica were investigated in terms of naproxen removal abilities. According to LC/MS data, A. niger was found the most efficient strain with 98% removal rate. Two main by-products of fungal transformation, O-desmethylnaproxen and 7-hydroxynaproxen, were identified by using LC/MS, 1HNMR, and 13CNMR. Our results showed that O-demethylation and hydroxylation of naproxen is catalyzed by cytochrome P450 enzyme system.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2016-0162/pdf

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