Anti-inflammatory activity of highly oxygenated terpenoids from Achillea biebersteinii Afan-Reference-Cited by-同舟云学术

Anti-inflammatory activity of highly oxygenated terpenoids from Achillea biebersteinii Afan

Published:2016-10-24 Issue:11-12 Volume:71 Page:429-432
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Mohamed Abou El-Hamd H.¹²,Mohamed Naglaa S.¹³,Hamed Ahmed R.⁴,Hegazy Mohamed-Elamir F.⁵

Affiliation:

1. Faculty of Sciences and Arts, Chemistry Department, Najran University, Najran, Saudi Arabia

2. Faculty of Science, Chemistry Department, Aswan University, Aswan, Egypt

3. Faculty of Science, Chemistry Department, Aswan University, Aswan, Egypt , Fax: +297-348-0450

4. Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza, 12622, Egypt

5. Phytochemistry Department, Natural Research center, El-Tahrir Street, Dokki, Giza, 12622, Egypt

Abstract

Abstract In continuation of our chemical investigation on some medicinal plants of the genus Achillea, chromatographic investigation of the methylene chloride/methanol (1:1) extract of the air-dried aerial part of Achillea biebersteinii Afan. (family Asteraceae) afforded a new natural monoterpene (2), in addition to two known sesquiterpenes (3 and 4). Compound 1 was isolated as light needle crystals. Structures were established on the basis of MS and NMR spectroscopic (1H, 13C, 1H-1H correlation spectroscopy, heteronuclear multiple-quantum coherence and heteronuclear multiple-bond correlation) data and in case of compound 1 were confirmed by X-ray analysis. All isolated compounds were examined for their anti-inflammatory activity to inhibit lipopolysaccharide-induced NO production in RAW264.7 macrophage cells. Compounds 3 and 4 produced a promising anti-inflammatory effect (76% and 80% inhibition, respectively). However, compounds 1 and 2 produced moderate inhibition of NO release recording a 41% and 36% inhibition of NO production, respectively.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2016-0098/pdf

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