Precocious sexual development in a male toddler caused by unrecognized transdermal exposure to testosterone: case report and review of the literature
Author:
Affiliation:
1. Division of Endocrinology , Boston Children’s Hospital , Boston , MA, USA
2. Department of Pediatrics , Harvard Medical School , Boston , MA , USA
Abstract
Publisher
Walter de Gruyter GmbH
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology, and Child Health
Link
https://www.degruyter.com/document/doi/10.1515/jpem-2020-0616/pdf
Reference12 articles.
1. Voelker, R. Children’s exposure to testosterone gel spurs FDA to order boxed label warning. J Am Med Assoc 2009;301:2428. https://doi.org/10.1001/jama.2009.810.
2. Martinez-Pajares, JD, Diaz-Morales, O, Ramos-Diaz, JC, Gomez-Fernandez, E. Peripheral precocious puberty due to inadvertent exposure to testosterone: case report and review of the literature. J Pediatr Endocrinol Metab 2012;25:1007–12. https://doi.org/10.1515/jpem-2012-0124.
3. Brachet, C, Heinrichs, C. Central precocious puberty after interpersonal transfer of testosterone gel: just a coincidence? J Pediatr Endocrinol Metab 2012;25:757–60. https://doi.org/10.1515/jpem-2012-0067.
4. Nelson, D, Ho, J, Pacaud, D, Stephure, D. Virilization in two pre-pubertal children exposed to topical androgen. J Pediatr Endocrinol Metab 2013;26:981–5. https://doi.org/10.1515/jpem-2013-0127.
5. Huynh, T, Stewart, CI. Virilisation in siblings secondary to transdermal ’bioidentical’ testosterone exposure. J Paediatr Child Health 2017;53:301–5. https://doi.org/10.1111/jpc.13466.
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1. Sexual precocity in the setting of parental use of a compounded testosterone cream: case report and review of the literature;Journal of Pediatric Endocrinology and Metabolism;2023-01-06
2. A review of adverse events in animals and children after secondary exposure to transdermal hormone‐containing medicinal products;Veterinary Record Open;2022-10-28
3. A Case of Peripheral Precocious Puberty May Be Caused by a Diet Containing Phytosterols in a 20-Month-Old Boy;Hormone Research in Paediatrics;2022
4. Testosterone;Reactions Weekly;2021-04
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