Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of <i>Croton oligandrus</i> Pierre ex. Hutch (Euphorbiaceae)-Reference-Cited by-同舟云学术

Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Croton oligandrus Pierre ex. Hutch (Euphorbiaceae)

Published:2023-02-22 Issue:7-8 Volume:78 Page:275-283
ISSN:0939-5075
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Tatsinda Tsapi Vanneck Bedel¹,Fotsing Fongang Yannick Stéphane²^ORCID,Awantu Angelbert Fusi³^ORCID,Kezetas Bankeu Jean Jules³,Lateef Mehreen⁴,Chouna Jean Rodolphe¹^ORCID,Nkeng-Efouet-Alango Pépin¹,Ali Muhammad Shaiq⁵,Lenta Bruno Ndjakou⁶

Affiliation:

1. Department of Chemistry , Faculty of Science , University of Dschang , P.O. Box 67 , Dschang , Cameroon

2. Department of Chemistry , Higher Teachers’ Training College , The University of Maroua , P.O. Box 55 Maroua , Cameroon

3. Department of Chemistry , Faculty of Science , The University of Bamenda , Bambili , Bamenda , Cameroon

4. Multi-Disciplinary Research Lab , Bahria University, Medical and Dental College , Karachi , Pakistan

5. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , 75270 , Karachi , Pakistan

6. Department of Chemistry , Higher Teacher Training College , University of Yaoundé I , P.O. Box 47 Yaoundé , Cameroon

Abstract

Abstract Crotofoligandrin (1), a new endoperoxide crotofolane-type diterpenoid was isolated from the dichloromethane/methanol (1:1) extract of the twigs of Croton oligandrus Pierre Ex Hutch along with thirteen known secondary metabolites including 1-nonacosanol (2), lupenone (3), friedelin (4), β-sitosterol (5), taraxerol (6), (−)-hardwickiic acid (7), apigenin (8), acetyl aleuritolic acid (9), betulinic acid (10), fokihodgin C 3-acetate (11), D-mannitol (12), scopoletin (13) and quercetin (14). The structures of the isolated compounds were determined based on their spectroscopic data. The crude extract and the isolated compounds were assessed in vitro for their antioxidant, lipoxygenase, butyrylcholinesterase (BChE), urease and glucosidase inhibitory potentials. Compounds 1–3, and 10 displayed activities on all the performed bioassays. All the tested samples showed strong to significant antioxidant activity with compound 1 being the most potent (IC50 39.4 μM).

Funder

Academy of Sciences for the Developing World

Deutscher Akademischer Austauschdienst

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2022-0204/pdf

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