Santalum Genus: phytochemical constituents, biological activities and health promoting-effects

Author:

Sharifi-Rad Javad1ORCID,Quispe Cristina2,Turgumbayeva Aknur34,Mertdinç Zehra5,Tütüncü Sena5,Aydar Elif Feyza5,Özçelik Beraat56,Anna Stępień-Warda7,Mariola Staniak7,Koziróg Anna8,Otlewska Anna8,Antolak Hubert8,Sen Surjit910ORCID,Acharya Krishnendu10,Lapava Natallia11,Emamzadeh-Yazdi Simin12,Martorell Miquel1314,Kumar Manoj15,Varoni Elena Maria1617,Iriti Marcello1817ORCID,Calina Daniela19

Affiliation:

1. Facultad de Medicina , Universidad del Azuay , Cuenca , Ecuador

2. Facultad de Ciencias de la Salud , Universidad Arturo Prat , Avda. Arturo Prat 2120, 1110939 , Iquique , Chile

3. Higher School of Medicine , Al-Farabi Kazakh National University , Almaty , Kazakhstan

4. School of Pharmacy , JSC “S. D. Asfendiyarov Kazakh National Medical University” , Almaty , Kazakhstan

5. Faculty of Chemical and Metallurgical Engineering, Department of Food Engineering , Istanbul Technical University , 34469 Maslak , Istanbul , Turkey

6. BIOACTIVE Research & Innovation Food Manufacturing Industry Trade LTD Co. , Maslak , Istanbul 34469 , Turkey

7. Department of Forage Crop Production , Institute of Soil Science and Plant Cultivation – State Research Institute , Czartoryskich 8, 24-100 Puławy , Poland

8. Faculty of Biotechnology and Food Sciences , Lodz University of Technology, Institute of Fermentation Technology and Microbiology , Wolczanska 171/173, 90 – 924 Lodz , Poland

9. Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany , University of Calcutta , 700019 , Kolkata , India

10. Department of Botany , Fakir Chand College , Diamond Harbour , West Bengal , 743331 , India

11. Medicine Standartization Department of Vitebsk State Medical University , Vitebsk , Republic of Belarus

12. Department of Plant and Soil Sciences , University of Pretoria , Gauteng 0002 , Pretoria , South Africa

13. Department of Nutrition and Dietetics, Faculty of Pharmacy , Centre for Healthy Living, University of Concepción , 4070386 Concepción , Chile

14. Universidad de Concepción, Unidad de Desarrollo Tecnológico , UDT, 4070386 Concepción , Chile

15. Chemical and Biochemical Processing Division , ICAR – Central Institute for Research on Cotton Technology , 400019 Mumbai , India

16. Department of Biomedical, Surgical and Dental Sciences , Università degli Studi di Milano , 20133 Milano , Italy

17. National Interuniversity Consortium of Materials Science and Technology (INSTM) , 50121 Firenze , Italy

18. Department of Agricultural and Environmental Sciences , Università degli Studi di Milano , 20133 Milano , Italy

19. Department of Clinical Pharmacy , University of Medicine and Pharmacy of Craiova , 200349 Craiova , Romania

Abstract

Abstract Santalum genus belongs to the family of Santalaceae, widespread in India, Australia, Hawaii, Sri Lanka, and Indonesia, and valued as traditional medicine, rituals and modern bioactivities. Sandalwood is reported to possess a plethora of bioactive compounds such as essential oil and its components (α-santalol and β-santalol), phenolic compounds and fatty acids. These bioactives play important role in contributing towards biological activities and health-promoting effects in humans. Pre-clinical and clinical studies have shown the role of sandalwood extract as antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroleptic, antihyperglycemic, antihyperlipidemic, and anticancer activities. Safety studies on sandalwood essential oil (EO) and its extracts have proven them as a safe ingredient to be utilized in health promotion. Phytoconstituents, bioactivities and traditional uses established sandalwood as one of the innovative materials for application in the pharma, food, and biomedical industry.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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