Santalum album L. alleviates cardiac function injury in heart failure by synergistically inhibiting inflammation, oxidative stress and apoptosis through multiple components
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Published:2024-07-15
Issue:1
Volume:19
Page:
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ISSN:1749-8546
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Container-title:Chinese Medicine
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language:en
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Short-container-title:Chin Med
Author:
Ding Bojiao, Jiang Li, Zhang Na, Zhou Li, Luo Huiying, Wang Haiqing, Chen Xuetong, Gao Yuxin, Zhao Zezhou, Wang Chao, Wang Zhenzhong, Guo Zihu, Wang YonghuaORCID
Abstract
Abstract
Background
Heart failure (HF) is a complex cardiovascular syndrome with high mortality. Santalum album L. (SAL) is a traditional Chinese medicine broadly applied for various diseases treatment including HF. However, the potential active compounds and molecular mechanisms of SAL in HF treatment are not well understood.
Methods
The active compounds and possible mechanisms of action of SAL were analyzed and validated by a systems pharmacology framework and an ISO-induced mouse HF model.
Results
We initially confirmed that SAL alleviates heart damage in ISO-induced HF model. A total of 17 potentially active components in SAL were identified, with Luteolin (Lut) and Syringaldehyde (SYD) in SAL been identified as the most effective combination through probabilistic ensemble aggregation (PEA) analysis. These compounds, individually and in their combination (COMB), showed significant therapeutic effects on HF by targeting multiple pathways involved in anti-oxidation, anti-inflammation, and anti-apoptosis. The active ingredients in SAL effectively suppressed inflammatory mediators and pro-apoptotic proteins while enhancing the expression of anti-apoptotic factors and antioxidant markers. Furthermore, the synergistic effects of SAL on YAP and PI3K-AKT signaling pathways were further elucidated.
Conclusions
Mechanistically, the anti-HF effect of SAL is responsible for the synergistic effect of anti-inflammation, antioxidation and anti-apoptosis, delineating a multi-targeted therapeutic strategy for HF.
Graphical Abstract
Funder
the Key R&D Projects of the Autonomous Region of China the Key R&D Projects of Shandong Province of China Yangling Demonstration Zone Seed Incubation Project
Publisher
Springer Science and Business Media LLC
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