Structural elucidation and neuroprotective activities of lignans from the flower buds of Magnolia biondii Pamp.
Author:
Ma Qinge12ORCID, Wei Rongrui1ORCID, Zhang Xiaodong3, Sang Zhipei2, Dong Jianghong4
Affiliation:
1. Key Laboratory of Modern Preparation of TCM of Ministry of Education, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004, China 2. College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang 473061, China 3. Department of Oncology and Hematology , Nanyang the First People’s Hospital , Nanyang 473002, China 4. College of Chemistry and Pharmaceutical Engineering , Huanghuai University , Zhumadian 463000, China
Abstract
Abstract
Two new lignans, 3,4-(10-methoxy-phenylallyl)-9″-((10′-isopropanol-3′,4′-furan)-phenylacetyl)-8″-dioxane-7″-O-β-d-glucopyranoside (1), 3,4-benzolactone-9″-((12′-isopropanol-3′,4′-furan)-phenylbutenone)-8″-dioxane-7″-O-β-d-glucopyranoside (2), and nine known lignan derivatives (3–11) were isolated from the flower buds of Magnolia biondii Pamp. for the first time. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS data, as well as by comparison with those of the references. Compounds (1–11) were evaluated for their neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells. As a result, compounds 1, 2, and 5 exhibited significant neuroprotective activities with IC50 values in the range of 3.08–6.12 μM.
Funder
Key Scientific Research Project of Colleges and University of Henan Province
Publisher
Walter de Gruyter GmbH
Subject
General Biochemistry, Genetics and Molecular Biology
Reference25 articles.
1. Zhang, X, Qian, F, Tan, JJ, Guo, FJ, Kulka, M, Xu, JW, et al. Bioassay-guided isolation of bisepoxylignans from the flower buds of Magnolia biondii Pamp. and their antiallergic effects. RSC Adv 2017;7:34236–43. https://doi.org/10.1039/c7ra01476g. 2. Feng, WS, Wang, JC, He, YH, Zheng, XK, Song, K, Zhang, YL, et al. Chemical constituents from the flower buds of Magnolia biondii Pamp. Chin Pharmaceut J 2015;50:2103–6. https://doi.org/10.11669/cpj.2015.24.003. 3. Guo, Q, Fang, H, Su, W. Lignans in flower buds of Magnolia biondii. Chin Tradit Herb Drugs 2004;35:849–52. https://doi.org/10.7501/j.issn.0253-2670.2004.8.389. 4. Chen, YY, Wang, B, Gao, CY, Qiao, L, Han, GQ. Study on the hydrophilic components of Magnolia biondii Pamp. Acta Pharm Sin 1994;29:506–10. 5. Feng, WS, He, YH, Zheng, XK, Wang, JC, Cao, YG, Zhang, YL, et al. Four new monoterpenoid glycosides from the flower buds of Magnolia biondii. Molecules 2016;21:1–7. https://doi.org/10.3390/molecules21060728.
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