Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin’i: A Case Series

Author:

Takayama Shin123,Arita Ryutaro12,Ono Rie12,Saito Natsumi12,Suzuki Satoko12,Kikuchi Akiko123,Ohsawa Minoru123,Tadano Yasunori2,Akaishi Tetsuya2,Tanaka Junichi2,Kanno Takeshi2,Abe Michiaki2,Onodera Ko2,Ishii Tadashi123

Affiliation:

1. Department of Kampo Medicine, Tohoku University Hospital

2. Department of Education and Support for Regional Medicine, Tohoku University Hospital

3. Department of Kampo and Integrative Medicine, Tohoku University Graduate School of Medicine

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference53 articles.

1. Altundag, A., Yildirim, D., Tekcan Sanli, D.E., Cayonu, M., Kandemirli, S.G., Sanli, A.N., Arici Duz, O. & Saatci, O. (2020) Olfactory cleft measurements and COVID-19-related anosmia. Otolaryngol. Head Neck Surg., 194599820965920.

2. Arita, R., Ono, R., Saito, N., Takayama, S., Namiki, T., Ito, T. & Ishii, T. (2020) Kakkonto, shosaikoto, platycodon grandiflorum root, and gypsum (a japanese original combination drug known as saikatsugekito): pharmacological review of its activity against viral infections and respiratory inflammatory conditions and a discussion of its applications to COVID‐19. Traditional and Kampo medicine, 7, 115-127.

3. Baker, H. & Genter, M. (2003) The Olfactory System and the Nasal Mucosa as Portals of Entry of Viruses, Drugs, and Other Exogenous Agents into the Brain. In Handbook of Olfaction and Gustation , 2nd ed., edited by Doty, R.L. & Marcel Dekker, New York, NY, pp. 549-574.

4. Boscolo-Rizzo, P., Borsetto, D., Fabbris, C., Spinato, G., Frezza, D., Menegaldo, A., Mularoni, F., Gaudioso, P., Cazzador, D., Marciani, S., Frasconi, S., Ferraro, M., Berro, C., Varago, C., Nicolai, P., et al. (2020) Evolution of altered sense of smell or taste in patients with mildly symptomatic COVID-19. JAMA Otolaryngol. Head Neck Surg., 146, 729-732.

5. Choi, E.S., Yoon, J.J., Han, B.H., Jeong, D.H., Lee, Y.J., Kang, D.G. & Lee, H.S. (2018) Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs. Phytomedicine, 38, 12-23.

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