Author:
Dziadosz Marek,Klintschar Michael,Teske Jörg
Abstract
AbstractBackground:As imatinib gained a lot of attention in the field of medicine, appropriate methods are needed for drug analysis. LC-MS/MS combined with complex sample preparation and column enrichment is usually the method of choice when high sensitivity is necessary. The application of LC-MSMethods:An LC-MSResults:The conditions applied resulted in a limit of detection/quantification value of 0.14/0.45 ng/mL reached without a sophisticated sample preparation technique or enrichment column application. It could be demonstrated that MSConclusions:The presented analytical strategy is an effective way of protein kinase inhibitor analysis in human serum.
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
Reference40 articles.
1. Liquid chromatographic method for detection and quantification of STI–571 and its main metabolite N-desmethyl-STI in plasma, urine, cerebrospinal fluid, culture medium and cell preparations;J Chromatogr B,2004
2. Simultaneous determination of AMN107 and imatinib (Gleevec®, Glivec®, STI571) in cultured tumour cells using an isocratic high-performance liquid chromatography procedure with UV detection;J Chromatogr B,2007
3. Determination of imatinib (Gleevec®) in human plasma by solid-phase extraction-liquid chromatography-ultraviolet absorbance detection;J Chromatogr B,2004
4. Simultaneous determination of nine tyrosine kinase inhibitors by 96-well solid-phase extraction and ultra performance LC/MS-MS;Clin Chim Acta,2011
5. HPLC-DAD protein kinase inhibitor analysis in human serum;J Chromatogr B,2012
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献