Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy-Reference-Cited by-同舟云学术

Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

Published:2021-07-09 Issue:12 Volume:10 Page:3215-3227
ISSN:2192-8614
Container-title:Nanophotonics
language:en
Short-container-title:

Author:

Semyachkina-Glushkovskaya Oxana¹²^ORCID,Fedosov Ivan²,Shirokov Alexander²³,Vodovozova Elena⁴,Alekseeva Anna⁴,Khorovodov Alexandr²,Blokhina Inna²,Terskov Andrey²,Mamedova Aysel²,Klimova Maria²,Dubrovsky Alexander²,Ageev Vasily²,Agranovich Ilana²,Vinnik Valeria²,Tsven Anna²,Sokolovski Sergey⁵,Rafailov Edik⁵,Penzel Thomas²⁶,Kurths Jürgen²⁷

Affiliation:

1. Humboldt University , Newtonstrasse 15 , 12489 Berlin , Germany

2. Saratov State University , Astrakhanskaya 82 , 410012 Saratov , Russia

3. Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences , Prospekt Entuziastov 13 , 410049 Saratov , Russia

4. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences , Miklukho-Maklaya 16/10 , 117997 Moscow , Russia

5. Optoelectronics and Biomedical Photonics Group, AIPT, Aston University , Birmingham , B4 7ET , UK

6. Charité-Universitätsmedizin Berlin, Sleep Medicine Center , Charitéplatz 1 , 10117 Berlin , Germany

7. Potsdam Institute for Climate Impact Research , Telegrafenberg A31 , 14473 Potsdam , Germany

Abstract

Abstract The blood-brain barrier (BBB) has a significant contribution to the protection of the central nervous system (CNS). However, it also limits the brain drug delivery and thereby complicates the treatment of CNS diseases. The development of safe methods for an effective delivery of medications and nanocarriers to the brain can be a revolutionary step in the overcoming this limitation. Here, we report the unique properties of the lymphatic system to deliver tracers and liposomes to the brain meninges, brain tissues, and glioma in rats. Using a quantum-dot-based 1267 nm laser (for photosensitizer-free generation of singlet oxygen), we clearly demonstrate photostimulation of lymphatic delivery of liposomes to glioma as well as lymphatic clearance of liposomes from the brain. These pilot findings open promising perspectives for photomodulation of lymphatic delivery of drugs and nanocarriers to the brain pathology bypassing the BBB. The lymphatic “smart” delivery of liposomes with antitumor drugs in the new brain tumor branches might be a breakthrough strategy for the therapy of gliomas.

Publisher

Walter de Gruyter GmbH

Subject

Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials,Biotechnology

Link

https://www.degruyter.com/document/doi/10.1515/nanoph-2021-0212/pdf

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