Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapy-Reference-Cited by-同舟云学术

Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapy

Published:2023-08-23 Issue:18 Volume:12 Page:3645-3652
ISSN:2192-8614
Container-title:Nanophotonics
language:en
Short-container-title:

Author:

Chen Xiao¹,Ma Xiaopeng²,Yang Gui¹,Huang Guan¹,Dai Haibing¹,Liu Nian³^ORCID,Yu Jianbo¹

Affiliation:

1. Longgang Central Hospital of Shenzhen , Shenzhen 518116 , China

2. School of Control Science and Engineering , Shandong University , Jinan 250061 , China

3. PET Center, Department of Nuclear Medicine , The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310003 , China

Abstract

Abstract The unique optical properties of squaraine dyes make them promising for cancer phototheranostics, but the reported squaraines for in vivo treatments mainly rely on their photothermal effect, where monotherapy cannot achieve the desired therapeutic effect. Here we generated a type of squaraine capable of killing tumors through both photothermal and photodynamic effects. We optimized squaraine structure with selenium modulation and formulated it into nanoparticles that showed strong absorption of infrared light, negligible fluorescence, good photothermal conversion (66.6 %), and strong photodynamic effects even after several irradiation cycles. In addition, the nanoparticles could be tracked through their strong optoacoustic signal. In mice, the nanoparticles effectively accumulated in tumors and eliminated them upon irradiation, without causing adverse effects. Our work demonstrates the potential of selenium modulation of squaraine for precise cancer diagnosis and treatment through synergistic photothermal and photodynamic effects.

Funder

Longgang District Medical and Health Technology Research Project

Natural Science Foundation of Zhejiang Province

Key Research and Development Plan in Shandong Province

National Natural Science Foundation of China

Publisher

Walter de Gruyter GmbH

Subject

Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials,Biotechnology

Link

https://www.degruyter.com/document/doi/10.1515/nanoph-2023-0358/pdf

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