Author:
Svoboda Jiří,Štádler Michal,Jandera Antonín,Panajotová Vladimíra,Kuchař Miroslav
Abstract
3-Substituted 1-benzothiophene-2-carboxanilides 2-5 and their corresponding sulfones 6-8 were synthesized. The antiinflammatory effect of compounds 2-8 was evaluated in tests of LTB4 biosynthesis, carrageenin edema and ear inflammation. With the exception of 3-hydroxyamides 5a-5c, low inhibitory activities against COX and LT biosynthesis were observed.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Palladium-Catalysed Intramolecular C–N versus C–C Coupling: The Effect of 1,8-peri-Interaction in the Naphthalene System;SynOpen;2019-01
2. An Easy Access to Novel Spiro-Fused Pyrrolo Benzo[b]thiophene 1,1-Dioxide Derivatives via 1,3-Dipolar Cycloaddition Using Benzo[b]thiophene 1,1-Dioxide;Synlett;2010-02-26
3. Synthesis of Benzo[b]thiophene Substituted Carbamates, Ureas, Semicarbazides, and Pyrazoles and Their Antimicrobial and Analgesic Activity;Phosphorus, Sulfur, and Silicon and the Related Elements;2009-07-13
4. Diels-alder reactions with cyclic sulfones: VIII. Organic catalysis in the synthesis of spiro[1-benzothiophene-4,5′-pyrimidine]-2′,4′,6′-trione 1,1-dioxides and 2′-thioxospiro[1-benzothiophene-4,5′-pyrimidine]-4′,6′-dione 1,1-dioxides;Russian Journal of Organic Chemistry;2009-01
5. Synthesis and characterization of substituted (benzo[b]thiophen-2-yl)-4-methyl-4,5-dihydro-1H-imidazol-5-ones;Journal of Heterocyclic Chemistry;2008-05