Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine
Author:
Affiliation:
1. Faculty of Pharmaceutical Science, Fukuoka University
2. Graduate School of Biomedical Sciences, Nagasaki University
3. Faculty of Medicine, University of Tsukuba
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/46/2/46_b22-00543/_pdf
Reference18 articles.
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2. 2) Yamano S, Takahashi A, Todaka T, Toki S. In vivo and in vitro formation of morphinone from morphine in rat. Xenobiotica, 27, 645–656 (1997).
3. 3) Todaka T, Ishida T, Kita H, Narimatsu S, Yamano S. Bioactivation of morphine in human liver: isolation and identification of morphinone, a toxic metabolite. Biol. Pharm. Bull., 28, 1275–1280 (2005).
4. 4) Kumagai Y, Todaka T, Toki S. A new metabolic pathway of morphine: in vivo and in vitro formation of morphinone and morphine-glutathione adduct in guinea pig. J. Pharmacol. Exp. Ther., 255, 504–510 (1990).
5. 5) Payabvash S, Beheshtian A, Salmasi AH, Kiumehr S, Ghahremani MH, Tavangar SM, Sabzevari O, Dehpour AR. Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver. Life Sci., 79, 972–980 (2006).
Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Opioids Alleviate Oxidative Stress via the Nrf2/HO-1 Pathway in LPS-Stimulated Microglia;International Journal of Molecular Sciences;2023-07-04
2. Activation of HSP90/HSF1 Signaling as an Adaptive Response to an Electrophilic Metabolite of Morphine;Biological and Pharmaceutical Bulletin;2023-02-01
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