Practical Synthesis of a 1.BETA.-Methylcarbapenem, J-111,225, Using 4-Mercapto-2-[4-(N-methylaminomethyl)phenyl] pyrrolidine as a Precursor.
Author:
Affiliation:
1. Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.
Publisher
Pharmaceutical Society of Japan
Subject
Drug Discovery,General Chemistry,General Medicine
Link
http://www.jstage.jst.go.jp/article/cpb/49/4/49_4_476/_pdf
Reference15 articles.
1. Carbapenem Derivatives as Potential Inhibitors of Various β-Lactamases, Including Class B Metallo-β-Lactamases
2. In Vitro Activities of Novel trans -3,5-Disubstituted Pyrrolidinylthio-1β-Methylcarbapenems with Potent Activities against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa
3. In vitro antibacterial activity and mechanism of action of J-111,225, a novel 1β-methylcarbapenem, against transferable IMP-1 metallo-β-lactamase producers
4. Therapeutic efficacy of J-111,225, a novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenem, against experimental murine systemic infections
5. Discovery of novel trans -3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems
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1. β-Lactams in the New Millennium. Part-I: Monobactams and Carbapenems;Mini-Reviews in Medicinal Chemistry;2004-01-01
2. Structure–Activity Relationships of 1β-Methyl-2-(5-phenylpyrrolidin-3-ylthio)carbapenems;Bioorganic & Medicinal Chemistry;2002-05
3. Chapter 4 Four-membered ring systems;A Critical Review of the 2001 Literature Preceded by Two Chapter on Current Heterocyclic Topics;2002
4. ChemInform Abstract: Practical Synthesis of a 1β-Methylcarbapenem, J-111,225, Using 4-Mercapto-2-[4-(N-methylaminomethyl)phenyl]pyrrolidine as a Precursor.;ChemInform;2001-09-25
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