C-Terminal Cysteine PEGylation of Adalimumab Fab with an Engineered Interchain SS Bond-Reference-Cited by-同舟云学术

C-Terminal Cysteine PEGylation of Adalimumab Fab with an Engineered Interchain SS Bond

Published:2020-03-01 Issue:3 Volume:43 Page:418-423
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Nakamura Hitomi¹,Anraku Makoto¹,Oda-Ueda Naoko¹,Ueda Tadashi²,Ohkuri Takatoshi¹

Affiliation:

1. Faculty of Pharmaceutical Sciences, Sojo University

2. Graduate School of Pharmaceutical Sciences, Kyushu University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/43/3/43_b19-00612/_pdf

Reference29 articles.

1. 1) Plückthun A, Skerra A. Expression of functional antibody Fv and Fab fragments in Escherichia coli. Methods Enzymol., 178, 497–515 (1989).

2. 2) King DJ, Adair JR, Angal S, Low DC, Proudfoot KA, Lloyd JC, Bodmer MW, Yarranton GT. Expression, purification and characterization of a mouse-human chimeric antibody and chimeric Fab′ fragment. Biochem. J., 281, 317–323 (1992).

3. 3) Sun C, Wirsching P, Janda KD. Enabling ScFvs as multi-drug carriers: a dendritic approach. Bioorg. Med. Chem., 11, 1761–1768 (2003).

4. 4) Röthlisberger D, Honegger A, Plückthun A. Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability. J. Mol. Biol., 347, 773–789 (2005).

5. 5) Harris JM, Chess RB. Effect of pegylation on pharmaceuticals. Nat. Rev. Drug Discov., 2, 214–221 (2003).

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