Experimental Study on the Effect of Tibetan Medicine Triphala on the Proliferation and Apoptosis of Pancreatic Islet β Cells through Incretin–cAMP Signaling Pathway
Author:
Affiliation:
1. Yunnan University of Chinese Medicine
2. The Second Affiliated Hospital of Yunnan University of Chinese Medicine
3. Yunnan Traditional Chinese Medicine Hospital
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/43/2/43_b19-00562/_pdf
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4. 4) Shao W, Wang Z, Ip W, Chiang YT, Xiong X, Chai T, Xu C, Wang Q, Jin T. GLP-1 (28-36) improves β-cell mass and glucose disposal in streptozotocin-induced diabetic mice and activates cAMP/PKA/β-catenin signaling in β-cells in vitro. Am. J. Physiol. Endocrinol. Metab., 304, E1263–E1272 (2013).
5. 5) Fatrai S, Elghazi L, Balcazar N, Cras-Méneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E. Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes, 55, 318–325 (2006).
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