Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats-Reference-Cited by-同舟云学术

Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats

Published:2020-03-01 Issue:3 Volume:43 Page:384-392
ISSN:0918-6158
Container-title:Biological and Pharmaceutical Bulletin
language:en
Short-container-title:Biol. Pharm. Bull.

Author:

Miyake Taiji¹

Affiliation:

1. Discovery ADMET Dept., Research Div., Chugai Pharmaceutical Co., Ltd.

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Link

https://www.jstage.jst.go.jp/article/bpb/43/3/43_b19-00641/_pdf

Reference34 articles.

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4. 4) Giacomini KM, Huang SM, Tweedie DJ, et al. Membrane transporters in drug development. Nat. Rev. Drug Discov., 9, 215–236 (2010).

5. 5) Zamek-Gliszczynski MJ, Lee CA, Poirier A, Bentz J, Chu X, Ellens H, Ishikawa T, Jamei M, Kalvass JC, Nagar S, Pang KS, Korzekwa K, Swaan PW, Taub ME, Zhao P, Galetin A. ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans. Clin. Pharmacol. Ther., 94, 64–79 (2013).

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