Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice

Author:

Miyake Taiji1ORCID,Tsutsui Haruka1,Haraya Kenta1ORCID,Tachibana Tatsuhiko1ORCID,Morimoto Kayoko2,Takehara Shoko2,Ayabe Miho3,Kobayashi Kaoru4,Kazuki Yasuhiro56ORCID

Affiliation:

1. Discovery ADMET Department, Research Division Chugai Pharmaceutical Co., Ltd. Gotemba Japan

2. Research and Development Department Trans Chromosomics, Inc. Yonago Japan

3. Discovery Technology Research Department, Research Division Chugai Pharmaceutical Co., Ltd. Kamakura Japan

4. Department of Biopharmaceutics Meiji Pharmaceutical University Kiyose Japan

5. Division of Genome and Cellular Functions, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine Tottori University Yonago Japan

6. Chromosome Engineering Research Center Tottori University Yonago Japan

Funder

Core Research for Evolutional Science and Technology

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

Pharmacology

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