Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice-Reference-Cited by-同舟云学术

Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice

Published:2021-09-06 Issue:21 Volume:178 Page:4335-4351
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:British J Pharmacology

Author:

Miyake Taiji¹^ORCID,Tsutsui Haruka¹,Haraya Kenta¹^ORCID,Tachibana Tatsuhiko¹^ORCID,Morimoto Kayoko²,Takehara Shoko²,Ayabe Miho³,Kobayashi Kaoru⁴,Kazuki Yasuhiro⁵⁶^ORCID

Affiliation:

1. Discovery ADMET Department, Research Division Chugai Pharmaceutical Co., Ltd. Gotemba Japan

2. Research and Development Department Trans Chromosomics, Inc. Yonago Japan

3. Discovery Technology Research Department, Research Division Chugai Pharmaceutical Co., Ltd. Kamakura Japan

4. Department of Biopharmaceutics Meiji Pharmaceutical University Kiyose Japan

5. Division of Genome and Cellular Functions, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine Tottori University Yonago Japan

6. Chromosome Engineering Research Center Tottori University Yonago Japan

Funder

Core Research for Evolutional Science and Technology

Japan Agency for Medical Research and Development

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.15612

Reference49 articles.

1. High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human