Therapeutic Potential of the Activators of the Nuclear Factor Erythroid 2-Related Factor 2–Antioxidant Response Element Pathway in Brain Disorders
Author:
Affiliation:
1. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
Publisher
Pharmaceutical Society of Japan
Subject
Pharmaceutical Science,Pharmacology,General Medicine
Link
https://www.jstage.jst.go.jp/article/bpb/40/5/40_b17-00091/_pdf
Reference30 articles.
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3. 3) Rada P, Rojo AI, Evrard-Todeschi N, Innamorato NG, Cotte A, Jaworski T, Tobón-Velasco JC, Devijver H, García-Mayoral MF, Van Leuven F, Hayes JD, Bertho G, Cuadrado A. Structural and functional characterization of Nrf2 degradation by the GSK-3/β-TrCP axis. Mol. Cell. Biol., 32, 3486–3499 (2012).
4. 4) Chen W, Sun Z, Wang XJ, Jiang T, Huang Z, Fang D, Zhang DD. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol. Cell, 34, 663–673 (2009).
5. 5) Dhakshinamoorthy S, Jain AK, Bloom DA, Jaiswal AK. Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H : quinone oxidoreductase 1 gene expression and induction in response to antioxidants. J. Biol. Chem., 280, 16891–16900 (2005).
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