A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway

Author:

Zhang Xiaojing1,Hu Huihui1,Luo Jingxiong1,Deng Huixing1,Yu Pei1,Zhang Zaijun1,Zhang Gaoxiao1,Shan Luchen1,Wang Yuqiang1

Affiliation:

1. Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference32 articles.

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2. 2) Neri M, Riezzo I, Pascale N, Pomara C, Turillazzi E. Ischemia/reperfusion injury following acute myocardial infarction: A critical issue for clinicians and forensic pathologists. Mediators Inflamm., 2017, 7018393 (2017).

3. 3) Lejay A, Fang F, John R, Van JA, Barr M, Thaveau F, Chakfe N, Geny B, Scholey JW. Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus. J. Mol. Cell. Cardiol., 91, 11–22 (2016).

4. 4) Chang W, Zhang M, Li J, Meng Z, Xiao D, Wei S, Chen L, Wang CY, Hatch GM. Berberine attenuates ischemia–reperfusion injury via regulation of adenosine-5′-monophosphate kinase activity in both non-ischemic and ischemic areas of the rat heart. Cardiovasc. Drugs Ther., 26, 467–478 (2012).

5. 5) Li X, Liu J, Lin L, Guo Y, Lin C, Zhang C, Yang B. Traditional chinese medicine shuang shen ning xin attenuates myocardial ischemia/reperfusion injury by preserving of mitochondrial function. Evid. Based Complement. Alternat. Med., 2014, 180965 (2014).

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