Different Diets Cause Alterations in the Enteric Environment and Trigger Changes in the Expression of Hepatic Cytochrome P450 3A, a Drug-Metabolizing Enzyme

Author:

Tajima Masataka12,Ikarashi Nobutomo1,Igeta Shintaro1,Toda Takahiro1,Ishii Makoto1,Tanaka Yoshikazu3,Machida Yoshiaki3,Ochiai Wataru1,Yamada Harumi2,Sugiyama Kiyoshi1

Affiliation:

1. Department of Clinical Pharmacokinetics, Hoshi University

2. Department of Pharmaceutical Sciences, International University of Health and Welfare

3. Division of Applied Pharmaceutical Education and Research, Hoshi University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference52 articles.

1. IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A

2. 2) Olinga P, Elferink MG, Draaisma AL, Merema MT, Castell JV, Pérez G, Groothuis GM. Coordinated induction of drug transporters and phase I and II metabolism in human liver slices. Eur. J. Pharm. Sci., 33, 380–389 (2008).

3. Antibiotics Suppress Cyp3a in the Mouse Liver by Reducing Lithocholic Acid-producing Intestinal Flora

4. Ciprofloxacin Suppresses Cyp3a in Mouse Liver by Reducing Lithocholic Acid-producing Intestinal Flora

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