A Possible Mechanism for 2,3′,4,4′,5′-Pentachlorobiphenyl-Mediated Decrease in Serum Thyroxine Level in Mice

Author:

Kato Yoshihisa1,Onishi Mao2,Haraguchi Koichi3,Ikushiro Shinichi4,Ohta Chiho5,Koga Nobuyuki5,Endo Tetsuya6,Yamada Shizuo2,Degawa Masakuni2

Affiliation:

1. Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

2. School of Pharmaceutical Sciences, University of Shizuoka

3. Daiichi College of Pharmaceutical Sciences

4. Faculty of Engineering, Toyama Prefectural University

5. Faculty of Nutritional Sciences, Nakamura Gakuen University

6. Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference33 articles.

1. 1) Safe SH. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit. Rev. Toxicol., 21, 51–88 (1990).

2. 2) Brouwer A, Longnecker MP, Birnbaum LS, Cogliano J, Kostyniak P, Moore J, Schantz S, Winneke G. Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. Environ. Health Perspect., 107 (Suppl. 4), 639–649 (1999).

3. 3) Kuratsune M, Yoshimura H, Matsuzaka J, Yamaguchi A. Epidemiologic study on Yusho, a poisoning caused by ingestion of rice oil contaminated with a commercial brand of polychlorinated biphenyls. Environ. Health Perspect., 1, 119–128 (1972).

4. 4) Masuda Y. Toxic effects of PCB/PCDF to human observed in Yusho and other poisonings. Fukuoka Igaku Zasshi, 100, 141–155 (2009).

5. 5) McFarland VA, Clarke JU. Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: Considerations for a congener-specific analysis. Environ. Health Perspect., 81, 225–239 (1989).

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