Synergistic Effects of 5-Fluorouracil and Gambogenic Acid on A549 Cells: Activation of Cell Death Caused by Apoptotic and Necroptotic Mechanisms via the ROS-Mitochondria Pathway

Author:

Su Jingjing1,Cheng Hui1,Zhang Dandan1,Wang Mei1,Xie Chenye1,Hu Yawen1,Chang Hebron Chun-Wei2,Li Qinglin1

Affiliation:

1. Key Laboratory of Xin’an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine

2. Department of Biotechnology, Asia University

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference34 articles.

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4. 4) Wang W, Yang SM, Su Y, Xiao ZY, Wang CY, Li XF, Lin L, Fenton BM, Paoni SF, Ding I, Keng P, Okunieff P, Zhang L. Enhanced antitumor effect of combined triptolide and ionizing radiation. Clin. Cancer Res., 13, 4891–4899 (2007).

5. 5) Murata S, Adachi M, Kioi M, Torigoe S, Ijichi K, Hasegawa Y, Ogawa T, Bhayani MK, Lai SY, Mitsudo K, Tohnai I. Etodolac improves 5-FU sensitivity of head and neck cancer cells through inhibition of thymidylate synthase. Anticancer Res., 31, 2893–2898 (2011).

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