Monitoring of Gefitinib Sensitivity with Radioiodinated PHY Based on EGFR Expression

Author:

Yoshimoto Mitsuyoshi12,Hirata Masahiko3,Kanai Yasukazu4,Naka Sadahiro5,Nishii Ryuichi6,Kagawa Shinya7,Kawai Keiichi2,Ohmomo Yoshiro3

Affiliation:

1. Division of Functional Imaging, National Cancer Center Hospital East

2. Faculty of Health Sciences, Kanazawa University

3. Osaka University of Pharmaceutical Sciences

4. Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine

5. Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine

6. Department of Radiology, Faculty of Medicine, University of Miyazaki

7. Research Institute, Shiga Medical Center

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference25 articles.

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2. 2) Laskin JJ, Sandler AB. Epidermal growth factor receptor: a promising target in solid tumours. Cancer Treat. Rev., 30, 1–17 (2004).

3. 3) Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol., 2, 127–137 (2001).

4. 4) Marshall J. Clinical implications of the mechanism of epidermal growth factor receptor inhibitors. Cancer, 107, 1207–1218 (2006).

5. 5) Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY, Nishiwaki Y, Vansteenkiste J, Kudoh S, Rischin D, Eek R, Horai T, Noda K, Takata I, Smit E, Averbuch S, Macleod A, Feyereislova A, Dong RP, Baselga J. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial). J. Clin. Oncol., 21, 2237–2246 (2003).

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