Alteration of Acetaminophen-induced Cytotoxicity in Mouse Hepatocytes during Primary Culture
Author:
Affiliation:
1. Department of Toxicology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
2. Present address: Mahasarakham university
Publisher
Pharmaceutical Society of Japan
Subject
Health, Toxicology and Mutagenesis,Toxicology
Link
http://www.jstage.jst.go.jp/article/jhs/55/5/55_5_767/_pdf
Reference34 articles.
1. 1) Mitchell, J. R., Jollow, D. J., Potter, W. Z., Davis, D. C., Gillette, J. R. and Brodie, B. B. (1973) Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J. Pharmacol. Exp. Ther., 187, 185-194.
2. 2) Hinson, J. A., Reid, A. B., McCullough, S. S. and James, L. P. (2004) Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab. Rev., 36, 805-822.
3. 3) Reid, A. B., Kurten, R. C., Mccullough, S. S., Brock, R. W. and Hinson, J. A. (2005) Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J. Pharmacol. Exp. Ther., 312, 509-516.
4. 4) Court, M. H. (2001) Acetaminophen UDP-glucuronosyltransferase in ferrets: species and gender differences, and sequence analysis of ferret UGT1A6. J. Vet. Pharmacol. Ther., 24, 415-422.
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1. In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin;Frontiers in Bioengineering and Biotechnology;2023-02-02
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