An Efficient Synthesis of a Potent Anti-inflammatory Agent, Viscolin, and Its Inducible Nitric Oxide Synthase Inhibitory Activity

Author:

Kuo Ping-Chung1,Chen Yi-Hsien2,Leu Yann-Lii3,Huang Chieh-Hung2,Liao Yu-Ren2,Lee E-Jian4,Yang Mei-Lin2,Wu Tian-Shung256

Affiliation:

1. Department of Biotechnology, National Formosa University

2. Department of Chemistry, National Cheng Kung University

3. Graduate Institute of Natural Products, Chang Gung University

4. Neurophysiology Laboratory, Neurosurgical Service, Departments of Surgery and Anesthesiology, and Institute of Biomedical Engineering, National Cheng Kung University Medical Center and Medical School

5. Department of Pharmacy, China Medical University

6. Chinese Medicine Research and Development Center, China Medical University and Hospital

Publisher

Pharmaceutical Society of Japan

Subject

Drug Discovery,General Chemistry,General Medicine

Reference12 articles.

1. The Inhibition of Superoxide Anion Generation in Human Neutrophils by Viscum coloratum

2. 2) Chiu S. T., “Flora of Taiwan,” 2nd ed., Vol. 2, Editorial Committee of the Flora of Taiwan, Taipei, 1996, pp. 282–285.

3. 3) Chiu S. T., Proceedings of International Symposium on Plant Biodiversity and Development of Bioactive Natural Products, Taichung, Taiwan, 2001, pp. 103–116.

4. Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway

5. Modulation of Inflammatory Genes by Natural Dietary Bioactive Compounds

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