Parent drug and/or metabolite? Which of them is most appropriate to establish bioequivalence of two oral oxcarbazepine formulations in healthy volunteers?

Author:

Girolamo Guillermo Di1,Opezzo Javier AW2,Schere Daniel3,Gonzalez Claudio D4,Moncalvo Juan J Rodriguez5

Affiliation:

1. Professor of Pharmacology Department of Pharmacology, School of Medicine, Paraguay 2215, Piso 16, CP: ZC1845, Ciudad Autónoma de Buenos Aires, Argentina- Universidad de Buenos Aires

2. Biochemistry - Analytical Unit- Laboratory of Clinical Tests and Nuclear Medicine, Dr M Schere, Juncal 1720/22 CP: 1062, Ciudad Autónoma de Buenos Aires, Argentina

3. Director of Laboratory of Clinical Tests and Nuclear Medicine, Dr M Schere, Juncal 1720/22 CP: 1062, Ciudad Autónoma de Buenos Aires, Argentina

4. Professor of Pharmacology School of Medicine - Instituto Universitario CEMIC Av Galvan 4102uay 2215, Piso 16, CP: C1431FWO, Ciudad Autónoma de Buenos Aires, Argentina

5. Medical Advisory Department IVAX Argentina, Juan José Castelli 6701 Munro, CP 1605, Provincia de Buenos Aires, Argentina

Publisher

Informa Healthcare

Subject

Pharmacology (medical),Pharmacology,General Medicine

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