The forgotten or underestimated relevance of biopharmaceutical-based assessments for the oral absorption studies of oxime reactivators-Reference-Cited by-同舟云学术

The forgotten or underestimated relevance of biopharmaceutical-based assessments for the oral absorption studies of oxime reactivators

Published:2016-05-04 Issue:7 Volume:12 Page:743-752
ISSN:1742-5255
Container-title:Expert Opinion on Drug Metabolism & Toxicology
language:en
Short-container-title:Expert Opinion on Drug Metabolism & Toxicology

Author:

Voicu Victor A.¹²,Medvedovici Andrei Valentin³,Sakurada Koichi⁴,Ohta Hikoto⁵,Rădulescu Flavian Ștefan⁶,Miron Dalia Simona⁶

Affiliation:

1. Department of Pharmacology, Toxicology and Clinical Psychopharmacology, University of Medicine and Pharmacy ‘Carol Davilla’, Bucharest, Romania

2. Medical Science Section, Romanian Academy, Bucharest, Romania

3. Department of Analytical Chemistry, University of Bucharest, Bucharest, Romania

4. Department of Forensic Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

5. Department of Forensic Chemistry, Toxicology Section, National Research Institute of Police Science, National Police Agency, Kashiwa City, Chiba, Japan

6. Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania

Funder

CNCS-UEFISCDI

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/17425255.2016.1179282

Reference95 articles.

1. Pharmacokinetics and pharmacodynamics of some oximes and associated therapeutic consequences: a critical review

2. Toxicological considerations of acetylcholinesterase reactivators

3. Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning

4. Structural requirements for effective oximes – Evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes

5. Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems

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2. Current approaches to enhancing oxime reactivator delivery into the brain;Toxicology;2019-07

3. In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?;Medicinal Chemistry;2018-04-05