Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems

Author:

Voicu Victor12,Rădulescu Flavian Ştefan3,Medvedovici Andrei4

Affiliation:

1. 1Romanian Academy, Medical Sciences Section, Calea Victoriei no. 125, Bucharest – 010071, Romania

2. 2University of Medicine and Pharmacy “Carol Davila”, Faculty of Medicine, Department of Clinical Pharmacology, Toxicology and Psychopharmacology, Şcoala Floreasca Street no. 8, Bucharest - 011643, Romania

3. 3University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Drug Industry and Pharmaceutical Biotechnology, Traian Vuia Street no. 6, Bucharest-020956, Romania

4. 4University of Bucharest, Faculty of Chemistry, Department of Analytical Chemistry, Panduri Ave., no. 90, Bucharest- 050663, Romania ;

Publisher

Informa Healthcare

Subject

Pharmacology,Toxicology,General Medicine

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